Antibacterial activity of N-pentylpantothenamide is due to inhibition of coenzyme a synthesis.
نویسندگان
چکیده
Growth inhibition by the pantothenate analog N-pentylpantothenamide (N5-Pan) has been attributed to the accumulation of acyl carrier protein carrying a prosthetic group modified by incorporation of N5-Pan. This was attributed to an inability of the AcpH acyl carrier protein phosphodiesterase to cleave the N5-Pan-modified prosthetic group from the protein moiety. We report that AcpH readily removes the N5-Pan-modified prosthetic group both in vivo and in vitro and show that N5-Pan blocks coenzyme A synthesis.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 54 3 شماره
صفحات -
تاریخ انتشار 2010